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20 As the rapid rise in atmospheric O 2 presented a new challenge for cellular energetics, single-celled life forms were forced to adapt, including giving rise to multicellular life

10.1038/s41598-018-32712-8 80 Lopes da FonsecaT.Villar-PiquA.OuteiroT

The heterogeneity caused by degradation will also affect the yield of the obtained proteins, and also increase the burden on downstream purification processes (Bryan et al