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Although subgroup analyses were performed, these are exploratory and may be underpowered, and residual confounding cannot be excluded MRI assessment relied on semi-quantitative MOAKS scoring rather than volumetric BML measurement, which may limit sensitivity to subtle structural changes

The cost of the intramuscular injection was taken from the Schedule of Benefits for Physician Services and was $6.75 for the first injection (fee code G373) and $3.89 for each additional injection or billed with a visit (fee code G372)

Milani ZH, Ramsden DB, Parsons RB (2013) Neuroprotective effects of nicotinamide N -Methyltransferase and its Metabolite 1-Methylnicotinamide