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There are four different methods namely dose by factor, similar drug, pharmacokinetically guided, and comparative approaches are described in literature to assess the initial dose.[1] The dose by factor method is an empirical approach and use the no observed adverse effect levels (NOAEL) of drug from preclinical toxicological studies to estimate human equivalent dose (HED).[2] Here, the dose selection is based on minimum risk of toxicity, instead of choosing one with minimum pharmacologic activity in humans

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Incorporating cruciferous vegetables like broccoli, Brussels sprouts, and cauliflower can provide the body with the precursors it needs to synthesize its own "master antioxidant." In addition to nutrition, sleep and stress management are non-negotiable