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We have shown that bTNF- induces a metabolic change in bFLS by significantly increasing glycolysis components and decreasing some components of the TCA cycle, which suggests that the inflammatory effect of bTNF- on bFLS is glucose metabolism-dependent

Moreover, astrocytic dysfunction disrupts the glymphatic system, impairing trauma-related memory processing during sleep and worsening PTSD symptoms [31,49]

In contrast, mitochondrial fusion supports cellular resilience by maintaining mitochondrial function, integrating metabolic activities, preserving mitochondrial integrity, and effectively scavenging ROS, thereby reducing lipid peroxidation and mitigating ferroptosis [56]

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