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BBB blood- brain barrier most approaches to delivery have utilized gene therapy methods with the hope that the growth factor will be expressed in the correct location at a high enough concentration and for a long enough period to provide clinical relief

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Here, the sodium salts of, for example, l-hydroxyethane-l,l-diphosphonate, diethy- lenetriamine pentamethylene phosphonate or ethylenediamine tetramethylene phospho- nate are used in amounts of 0.1 to 5 wt

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