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This reparative effect is mediated, at least in part, through the upregulation and reorganization of key regulatory proteins, most notably protein kinase C (PKC) and the tight junction scaffolding protein zonula occludens-2 (ZO-2), thereby facilitating the reassembly and functional recovery of the tight junction complex (161)

FIGURE 9 The lung histopathologic analysis at 8 weeks post-infection also revealed multiple, large, and poorly demarcated granulomatous lesions in all M