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for example, I know a smoker who has one fag in the morning, and one at night, and fill in the rest of the day with an e-cig

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People have thought for some time that depressed smokers have difficulty quitting because they experience a more pronounced withdrawal syndrome, but the evidence is scarce because depressed smokers are hard to recruit and consequently have not been as studied, said coauthor Lee Hogarth, associate professor of psychology at the University of Exeter in England