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(8) Research has demonstrated that SAM is a universal methyl donor required for numerous cellular methylation reactions including DNA and histone methylation

In laboratory research models, GSH exerts its antioxidant activity through direct scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as through serving as an essential cofactor for glutathione peroxidase (GPx) enzymes, which catalyse the reduction of hydrogen peroxide and lipid hydroperoxides to non-toxic products

Additionally, paclitaxel-resistant PCa cells often upregulate the expression of the antiapoptotic protein Bcl-2 and increase GSH levels, further enhancing antioxidant defense and resistance

There was a less significant but still noticeable reduction in total cholesterol, HDL cholesterol, and non-HDL cholesterol