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American Journal of Physiology

As a general guideline for the protection of public health, the US EPA establishes a threshold range for tolerable risk between 1.00E-4 and 1.00E-6 (i.e., the likelihood that an individual will develop cancer from lifetime exposure to a carcinogen is 1 in 10,000 to 1 in 100,000) [9, 42, 43]

In fact, heavy use of alcohol can permanently damage the genes involved in healthy sleep and wake cycles, she told Healthline