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Moreover, treatment with 10 ng/mL of IGF-1 for 10 days was demonstrated to be sufficient to induce tenogenic differentiation of bone marrow MSCs in 3D in vitro culture with significant upregulation of tenocytic markers (SCX, collagen type III, and decorin) (Durgam et al., 2012)

doi: 10.1038/s41380-023-02243-4 287 ZhuY.WangX.ZhouX.DingL.LiuD.XuH

A systematic evaluation of peripheral cytokines (e.g., via multiplex Luminex assays) will be conducted in follow-up studies to map gut-derived immune signals to CNS pathology

It activates the ROS/JNK signaling pathway while inhibiting the Akt/mTOR pathway, leading to G2/M phase arrest and triggering autophagy (53)