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This integrated analysis of the chromatin landscape and BCL-2 transcription in well-defined subtypes of CRPC with contrasting AR signaling activity 78 suggests that the increased BCL-2 expression in AR -/lo CRPC may result from not only a loss of AR-mediated BCL-2 repression but also active BCL-2 transcription mediated by other transcription factors such as NF-B, STAT3 and E2F1 33,36,42 bound to these newly available chromatin loci

Like many medications in this class, the most common side effects are nausea, diarrhea, or stomach upset , especially when starting treatment

You head to the kitchen and grab a snack