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Researchers confirmed this through knockout studies in mice, where animals lacking beta-3 adrenergic receptors showed zero response to AOD 9604, proving the peptide works specifically through this receptor pathway in adipose tissue

[27] ROSEN, R.C

Although high doses of NR (8 g/d) exhibited certain improving effects on lactation performance, its inherent bitter taste can compromise palatability and reduce feed intake, particularly during the first week postpartum