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Pen Dosage Chart Dosage & Protocols Variations Standard Research Protocol Dose: 5 10 mg daily (= 1530 clicks) Duration: 2 4 weeks Frequency: Daily Cycle Interval: 2-week pause Goal / Description: For baseline NAD+ and fat metabolism studies

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one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy