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As described previously 26 , we detected increases of the mRNA and protein levels of VEGF and PlGF as well as the concentrations of secreted VEGF and PlGF in HG-treated hRECs

Appl Biochem Biotech 158:213221

Another reason is that DAO activity in the blood does not necessarily indicate activity in the rest of the body

We examined gene sets enriched or suppressed upon KPT-330 treatment using Gene Set Enrichment Analyses (GSEA) 42 and observed 32 hallmark gene sets significantly enriched or suppressed (Supplementary Data 4)