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Epub 2024 Jul 4

cAMP-responsive element modulator (CREM) is a tissue-specific transcriptional repressor in immune cells

Ca 2+ -activated calcineurin dephosphorylates BAD, enhancing its proapoptotic activity

This decline is due to neuronal loss, formation of neurofibrillary tangles (NFTs) and amyloid plaques, ultimately resulting in neuronal death and tissue atrophy (155)