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Early phase circulating GSTA2 ( EPC GSTA2) protein was an indicator of hepatic injury and a prognostic biomarker of HCC recurrence A significantly higher level of EPC GSTA2 protein was detected in HCC recipients ( N = 106) compared to the healthy donors and in pretransplant plasma of the recipients (Fig

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This possible gene-environment interaction seems to be biologically plausible, since it has been shown that GSTP1 Val allele is more catalytically efficient towards benzo-diol-epoxides found in tobacco smoke 52

Both histamine and Hcy require methylation for their metabolism, which suggests that hypomethylation may cause histamine intolerance in MCAS and EDS