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In patients with AD, elevated labile copper levels in cerebrospinal fluid (CSF) and cortical regions, particularly within A plaques, exacerbate mitochondrial dysfunction by inhibiting Complex IV and depleting glutathione (GSH), creating a vicious cycle of oxidative damage (9)

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Biol Trace Elem Res 200(12):49364948 Costello LC, Franklin RB (2017) Decreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas