acetaminophen glutathione toxicity Paracetamol Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research 10 days of MCQ! Day 3: Acetaminophen Overdose Answer: C N acetylcysteine (NAC) NAC is the antidote for acetaminophen overdose. It works by replenishing hepatic glutathione stores, which are rapidly depleted Acetaminophen overdose resulting in massive hepatic necrosis. Note the scant residual periportal hepatocytes. #liverpath #hepatology

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