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Although previous studies identified that RIDD functions mainly in the clearance of ER-bound transcripts as a mechanism to reduce the load of ER client proteins during ER stress, more recent studies have also revealed an active role of RIDD in determining cell fate 61

Unchecked, they could lead to neurodegenerative diseases like Parkinsons, a drop in quality of life and depression

326 However, alosetron may cause significant side effects including severe constipation and loss of blood flow to the colon, although the latter is fairly uncommon

Esazadeh et al., 2024), while other authors claim that it is generally safe (Shaw, 2018)