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Microglia are also directly involved in MS by producing cytokines such as tumor necrosis factor- (TNF-) and interferon- (IFN-), superoxide (O 2- ) or nitric oxide (NO), and release of proteolytic and lipolytic enzymes, which can destroy the myelin sheath [15,18]

Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity

446 However, pathological effects emerge when immune clearance fails, leading to senescent cell accumulation and SASP-driven fibrosis in the tissue microenvironment

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