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In the GPX4-dependent ferroptosis pathway, the CNC transcription factor NFE2L2/NRF2 plays a crucial regulatory role by activating GPX4 through SLC7A11 to suppress ferroptosis [136]

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Giglio P, Gagliardi M, Tumino N, Antunes F, Smaili S, Cotella D, et al

Thus, near-to-invariably, these approaches would study SNPs known or expected to influence cellular or organismal processes linked to CDDP sensitivity, such as CDDP extrusion (e.g., SNPs affecting ABCC2), DNA damage-elicited signal transduction (e.g., SNPs affecting ERCC1), apoptosis (e.g., SNPs affecting caspases) or immune responses (e.g., SNPs affecting cytokines or their receptors)