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Uric acid cannot neutralize free radicals such as hydrogen peroxide, hydroxyl radicals, O 2 -, and peroxynitrite and exhibits fewer antioxidant properties against radicals such as CH 3 (methyl radical) and tert-butyl hydroxyperoxide

Additionally, oxidized phosphatidylserine inhibits nitric oxide production and downregulates inducible nitric oxide synthase and IL-1 gene expression by modulating c-Jun N-terminal kinase phosphorylation and nuclear translocation of NF-B, effects not observed with native phosphatidylserine [9]

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