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However, in contrast to these preclinical data using parenteral drug administration, no differences were found in the hysteresis curves between lisdexamfetamine and D-amphetamine in the present study using oral drug administration, further supporting the similarity of the two substances when used orally in humans

If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy