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Table 4: Reasons to use medication to lower uric acid Gout with more than two flares a year, whether due to overproduction of uric acid or difficulty excreting it Chronic visible collections of uric acid (tophi) High uric acid in the urine (over 800mg per 24 hours), especially if history of kidney stone Failure of other options to control the arthritis of gout (for example, failure of probenecid) When a person is receiving chemotherapy for a leukemia or a lymphoma and it is expected that many tumor cells will be killed (since one of the breakdown products of cells is purine which gets broken down to uric acid) iii

Thyroid Function : Rare reports of temporary thyroid function changes, though causation remains unclear in research literature

It's one of the most underdiagnosed causes of chronic musculoskeletal pain

And safety runs through all of it allergies and anaphylaxis, electrolyte and osmolarity considerations, fluid overload in patients with heart or kidney disease, and G6PD screening before any high-dose vitamin C or oxidative therapy