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Conversely, H3K4me2, an activating mark associated with gene expression, decreases by 65%, reducing expression of genes essential for sperm development (92)

Systematic literature search A systematic literature review on BH 4 and related names was performed in spring 2017 on Pubmed, Cochrane database, and the Cinahl database, using the following search terms: Tetrahydrobiopterin deficiency, BH 4 deficiency, atypical PKU, atypical phenylketonuria, PTPS deficiency, (6-)pyruvoyl-tetrahydropterin synthase deficiency, SR deficiency, sepiapterin reductase deficiency, segawa(s) disease, GTPCH (I) deficiency, GTP cyclohydrolase (I) deficiency,Guanosine (-5-) triphosphate cyclohydrolase (I) deficiency, DHPR deficiency, dihydropteridine reductase deficiency, pterin (-4a-) carbinolamine dehydratase deficiency, PCD deficiency

The original Achilles tendon transection model in rats (Staresinic, Sikiric et al., 2003) showed that systemic BPC-157 accelerated healing of fully transected tendons, and this finding has been reproduced across multiple labs over the 20+ years since

Following relevance-based screening, approximately 20 to 35 studies were included in the final narrative synthesis