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In addition to interfering with inflammatory pathways, scoparone has been shown to provide protection from oxidative stress, as demonstrated in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and lipid peroxidation assays in vitro (151, 153), and to inhibit production of ROS and preserve antioxidant enzyme activity in response to several types of oxidative stressors (154, 155)

Somal et al., 2023)

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The challenge of conducting internal control experiments, such as one limb versus opposite limb control, is due to the systemic transfer of BPC157 when applied orally or injected systemically, making it difficult to isolate the effects on a specific injury site 6m30s