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their association with synapses can change rapidly, thus affecting the volume of the synaptic cleft, as well as the efficacy of ion and neurotransmitter buffering and removal

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Inhibiting the glutathione system induces ferroptosis, a non-apoptotic form of cell death driven by lipid peroxidation, with compounds like withaferin A and altretamine showing strong preclinical activity

In OA studies, direct intra-articular injection of Fer-1 into mouse or rat models significantly reduced the accumulation of lipid peroxidation end-products like MDA and 4-HNE in cartilage tissue, alleviated the degree of ECM degradation, and improved overall joint pathology scores