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Description

A Cleveland Clinic review notes that one case report described symptoms only after a cumulative 15,000 mcg (15 mg) of injected B12 over several weeks

This is known as double crush syndrome , where nerve irritation exists at more than one location

Acta 657 , 4755 (2017) P

However, it should be noted that both of these trials were conducted on a small sample size and further large-scale clinical trials are needed to provide more information on the clinical relevance of these treatments