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Mater Sci Eng C Mater Biol Appl (2020) 113:111004

Cai et al., 2023)

These drugs mediate the release of DAMPs following hepatocyte injury, which are sensed by, for example, Kupffer cells (KCs), activating innate immune receptors to trigger intracellular events leading to the release of pro-inflammatory mediators, cytokines, and chemokines, and then recruit neutrophils and monocytes to the blood in a sterile inflammatory process

Some reports indicate that diabetes may negatively impact the mesenchymal stem cell pool, suggesting that ADSCs from individuals with type 2 diabetes mellitus (T2DM) could exhibit reduced regenerative capacity