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In hepatocellular carcinoma (HCC), activation of PHGDH promotes the synthesis of GSH and NADPH, markedly reducing intracellular ROS levels

Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice

The latter modification is consistent with our recent report that parkin thiols participate in redox chemistry to neutralize highly reactive molecules , e.g., H 2 O 2 and dopamine metabolites [53], as well as with the literature on transient S- glutathionylation of redox-sensitive proteins as a cytoprotective mechanism against rising concentrations of ROS [27]

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