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To ensure that the K408R mutation did not lead to post gestational developmental changes that would confound the presentation of age-related impairment, we assessed the weights and motor abilities of pups at P21

56 A couple of early open-label studies showed significant blood-pressure-lowering effects of CoQ10 in patients with essential hypertension: one showed a reduction from 164.5 to 146.7 mmHg for systolic and from 98.1 to 86.1 mmHg for diastolic blood pressure