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It should be noted that for benchmarking purposes we recommend using LogS expressed in mole fraction, as it provides a dimensionless and cross-solvent comparable target, while mass-based solubility (LogS(g/100 g)) is more usable for practical relevance 39 , also being a proper target for ML models development

While specific downregulation kinetics for Dihexa haven't been thoroughly characterized in published literature, research on HGF and c-Met signaling in other contexts suggests receptor density begins declining within 2448 hours of sustained agonist exposure, with maximum downregulation occurring around 72 hours

FDA approval is informative

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