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Furthermore, SQSTM1 is capable of interacting with Raptor, a part of mTORC1, and colocalizing with Rag GTPases at the lysosomal membrane, hence being responsible for the activation of mTORC1 (Linares et al., 2013)

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Similarly, histone acetylation events promoting gene expression and cancer progression require acetyl-CoA, which can be derived from BCAAs and lysine 22