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Addressing the underlying condition first, or simultaneously, is the clinical approach at Perfect B

A modified mutant human NNMT (mt-hNNMT) [lacking 3 amino acid residues from the C-terminus of the NNMT protein that was not observed in crystal structure] (3ROD, PDB accession code) cloned into an IPTG-inducible plasmid pJ401 expression vector was purchased from DNA 2.0 (Menlo Park, Calif.)

The peptide consists of nine amino acids in the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, forming a unique neuropeptide with distinctive biological properties

This has generated strong research interest in epithalon as a potential treatment for a variety of inflammatory ailments including arthritis and ulcerative colitis