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doi:10.1507/endocrj.ej12-0106 Vakil M, Park S, Broder A

This suggests that biochemical and objective responses may not predict overall benefit from BAT for some patients

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First, it was shown in vitro that treatment of astrocytes with acetyl-L-carnitine (30-100 M) induces vitagene HO-1 in a dose- and time-dependent manner and that this effect was associated with up-regulation of another vitagene HSP60 as well as high expression of the redox-sensitive transcription factor Nrf2 in the nuclear fraction of treated cells [121]