chac1 er stress glutathione degradation CHAC1: a master regulator of oxidative and ferroptosis in human diseases and cancers CHAC2 is essential for self-renewal

CHAC2 is essential for self renewal and glutathione maintenance in human embryonic stem cells ScienceDirect CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element* Journal of Biological Chemistry Human ChaC1 but not human ChaC2 is induced specifically by ER stress Download Scientific Diagram

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