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Thyroid hormone and estradiol have overlapping effects on kidney glutathione s-transferase-alpha gene expression

When CYP1A2 (Phase I) oxidizes an aromatic amine to its N-hydroxy derivative, and then O-acetyltransferase activity (catalyzed by the same NAT enzymes) transfers an acetyl group to the oxygen, it creates a highly reactive N-acetoxyarylamine that binds DNA

Notably, activation of TLR7 and TLR9 through this pathway induces type I interferon (IFN) responses, involving TRAF3 and IRF7