glutathione reaction disulfide Is Required to Regulate the Formation of Native Bonds within Proteins Entering the Secretory Pathway* reduced oxidized glutathione Glutathione Disulfide

Since the upregulation of these phase-II detoxification enzymes regulated in part by the transcription factor, Nrf2, provides cellular protection from oxidative stress, we next asked whether exposure of microglia to various forms of -synuclein enabled an antioxidant response

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These shear stress-induced changes involve the activation of Jun N-terminal kinase (JNK) signaling and the downregulation of extracellular signal-related kinase (ERK) and glycogen synthase kinase (GSK)3 [224, 225]

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