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Cigarette butts contain toxins (such as heavy metals and the organic compounds nicotine and ethylphenol) and not a lot is known about how those toxins impact the environment, wildlife, and humans

DNA hypermethylation always leads to transcriptional suppression and decreased gene expression, while DNA hypomethylation influences chromosome stability or enhanced aneuploidy [7]

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The next section will review some of the current arguments and evidence in e-cigarette debates, including the toxicology of e-cigarettes and the arguments about the use of e-cigarettes as a harm reduction tool, which have been used as evidence for pursuing a particular regulatory approach