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Although it is still unknown why these BCAA levels are elevated and why they associate with insulin resistance, a dysfunctional BCAA catabolism may be one of the underlying factors

Physiol Rev (2010) 90(1):20758

Clinical diagnosis of organic acid metabolism disorders can be assisted by gas-liquid chromatography examination of organic acids and their derivatives in urine and blood, and other auxiliary diagnostic methods include electroencephalogram, cranial nuclear magnetic resonance, enzyme analysis, and genetic testing, etc