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Secondly, this study is an observational study, and therefore, the causality could not be concluded

As long as the brain fails to revert to a healthier relationship between nerve cells and blood vessels, the result is long-term neurovascular coupling dysfunction, which inevitably leads to long-term symptoms of TBI

This regulatory pathway has also been studied and reviewed extensively (6, 17, 18, 29, 63, and references contained therein)

Pharmacological treatment of BD, which is of great importance in the clinical management of BD, has also critical effects on gut microbiota, opening the opportunity to use this knowledge as potential biomarkers