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5 There is increased aromatase, which produces estrogen, as well as decreased 17-hydroxysteroid dehydrogenase 2 (17-HSD2), which breaks down estradiol to estrone, a more inert form of estrogen

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it has a vital role in spermatogenesis and spermatozoon maturation [73,87], it inhibits viral infections (e.g., influenza) [88], it has an important role in the pathogenesis of different diseases such as cancer, inflammation, protein deficiency, Alzheimers disease, Parkinsons disease, hepatic diseases, cystic fibrosis, HIV, heart attacks, hemorrhagic stroke, diabetes, pulmonary disease, gastritis, duodenal ulcer, pancreatic disease, kidney disease, rheumatoid arthritis (RA), autoimmune thyroiditis, muscular dystrophy, amyotrophic lateral sclerosis, preeclampsia, cataract, glaucoma, atherosclerosis, and asthma [37,51,52,73,85,89,90,91,92,93,94,95,96]

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