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Thiol donors and analogues (GSH and mucolytic medications, such as N-acetyl-L-cysteine, nacystelyn, erdosteine, and carbocysteine lysine salt), dietary polyphenols, and flavonoids (curcumin, resveratrol, green tea-catechins, quercetin) have all been shown to scavenge and detoxify free radicals and oxidants, raise intracellular thiol levels, regulate NF-\( \kappa \) activation, and ultimately suppress the expression of inflammatory genes [102] (Table 3)

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In particular, several previously highlighted genes, including ANXA1 and RAN , showed directionally consistent L-serineassociated trends along the trajectories in this sensitivity analysis (Supplementary Fig