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In a normal dose of 1 gram of acetaminophen four times a day, one-third of patients may have an increase in their liver function tests to three times the normal value.[36] However, it is unclear as to whether this leads to liver failure.[37] Since paracetamol is often included in combination with other drugs, it is important to include all sources of paracetamol when checking a person's dose for toxicity

An acetaminophen concentration of 14 mcg/mL at presentation aroused suspicion that acetaminophen might have caused the patients liver failure, despite her adamant denial of overdose

Because the techniques utilised during the execution of an RCT minimise the potential of confounding factors influencing the outcomes, it is thought to provide the most credible data on the effectiveness of treatments