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Production of citrinin by Penicillium chrysogenum in bread

In a different study, the impact of methotrexate was evaluated in a Swiss mouse skin tumor model methylcholanthrene (MCA)

The positive anti-tumor effects of SAHA notwithstanding, it is crucial to highlight the elevated toxicity observed with high doses of the drug, resulting in adverse effects like fatigue, diarrhea, anorexia, dehydration, myelosuppression, thrombocytopenia, among others (Mrakovcic et al., 2017)