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Furthermore, the cross-regulatory mechanism not only provides multi-target combination strategies for therapy, such as targeting the HOTAIR-EZH2 axis, combining DNMT inhibitors with miR-152 mimics, and inhibiting m6A to reduce circPLPP4 stability, but also highlights the importance of combined detection of biomarkersfor instance, the combined use of biomarkers like SFRP5 methylation and miR-137, which overcomes the limitations of single-molecule detection

[24] Yamada M, Tsukimura N, Ikeda T, Sugita Y, Att W, Kojima N, et al

PMID 7854453