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In contrast, pre-incubation with 3M LCS3 did not affect the amount of inhibition, suggesting that LCS3 inhibits GSR by a reversible mechanism (Fig

In particular, a different metabolic pattern emerged between the two groups, highlighting the possible metabolic biomarkers associated with the risk of the disease, such as urea abundance, uric acid, serine and threonine in both plasma and BM of MM patients, likely associated with impaired kidney function during MM progression