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In this model, genes associated with the one-carbon metabolic pathways, including the folate and methionine cycles, are up-regulated in the fungal cells upon infection, and are supposed to result in enhanced biosynthesis of nucleotides, NADPH, glutathione and methyl groups

By reducing systemic inflammation, the KD may help alleviate pelvic pain and other inflammatory symptoms associated with the disease [11,12,13]

Given the broad and orthogonal substrate scopes established for Cp1B and Cp1D, a library of more than 1,200 E-64 analogs can be generated in one-pot reactions