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There is an urgent need to understand how SARS-CoV-2 regulates host cellular responses and hijacks host cells to escape degradation/clearance

Pathology of retinal pigment epithelium during age-related macular degeneration The RPE, a single layer of polarized cells that is situated between the rods and cones and the choriocapillaris in the outermost portion of the retina, undergoes major pathological changes during AMD progression (24, 25) (Figure 1)

Dual role of ROS as signal and stress agents: iron tips the balance in favor of toxic effects

Cell Biochem Funct 42(6):e4100 Banks WA, Rhea EM (2021) The bloodbrain barrier, oxidative stress, and insulin resistance