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Moreover, compromised intestinal barrier integrity and gut-derived microbial components such as LPS activate TLR/NF-B/NLRP3 pathways, which not only drive systemic inflammation but also modulate gut-derived tryptophan metabolism and serotonin synthesis, thereby coupling immune regulation with neuromodulatory functions

Anti-IL-23p19 antibodies, such as risankizumab, guselkumab, brazikumab, and mirikizumab, have also demonstrated efficacy and favorable safety profiles [317, 318]

Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia

All the determinations were made in triplicate and presented as the mean of three values SD